KMID : 1135520140100010002
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Korean Journal of Exercise Rehabilitation 2014 Volume.10 No. 1 p.2 ~ p.8
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Treadmill exercise improves short-term memory by enhancing neurogenesis in amyloid beta-induced Alzheimer disease rats
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Kim Bo-Kyun
Shin Mal-Soon Kim Chang-Ju Baek Sang-Bin Ko Yeong-Chan Kim Young-Pyo
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Abstract
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Alzheimer¡¯s disease is one of the most devastating neurodegenerative disorders, and this disease is characterized by severe memory impair-ment and decline of cognition. Hippocampal neurons are vulnerable to injury induced by Alzheimer¡¯s disease. Physical exercise is known to promote cell survival and functional recovery after brain injuries. In the present study, we investigated the effects of treadmill exercise on short-term memory in relation with neurogenesis in the rats with amyloid ¥â25-35 (A¥â25-35)-induced Alzheimer¡¯s disease. The rat model of Alzheimer¡¯s dis-ease was induced by the intracerebroventricular (ICV) injection of A¥â25-35, using a stereotaxic instrument. The rats in the exercise group were forced to run on a treadmill for 30 min once daily for 4 consecutive weeks, starting 2 days after A¥â25-35 injection. Presently, short-term memory was deteriorated and apical dendritic length in the hippocampus was short-ened in the hippocampus by A¥â25-35 injection. In contrast, treadmill exer-cise alleviated memory impairment and increased apical dendritic length in the A¥â25-35-injected rats. Neurogenesis and brain-derived neurotor-phic factor (BDNF) and tyrosine kinase B (trkB) in the hippocampal den-tate gyrus were decreased by A¥â25-35 injection. Treadmill exercise in-creased neurogenesis and expressions of BDNF and trkB expressions. The present study shows that treadmill exercise may provide therapeu-tic value for the alleviating symptoms of Alzheimer¡¯s disease.
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KEYWORD
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Alzheimer¡¯s disease, Treadmill exercise, Short-term memory, Neurogenesis, Apical dendritic length
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